Blood test could predict Alzheimer's three years in advance of
10 March 2014
A team of US researchers is patenting a blood test for Alzheimer's or
mild cognitive impairment (MCI) based on 10 lipid biomarkers associated
with the diseases.
The researchers, from seven institutions, say the test can predict
with 90 percent accuracy if a healthy person will develop the
diseases within three years and those who would remain normal in the
near future. This isn't the first research to indicate
dementia-related diseases could be predicted from a diagnostic test.
See below for other Alzheimer's research published on MTB Europe
They say the panel reveals changes in the breakdown of neural
cell membranes resulting in 10 identifiable lipids, or metabolites,
circulating in the blood. In particular, two of the 10 metabolites
have strong links to the neuropathology of Alzheimer’s. The research
has been published online in Nature Medicine.
“Our novel blood test offers the potential to identify people at
risk for progressive cognitive decline and can change how patients,
their families and treating physicians plan for and manage the
disorder,” says the study’s corresponding author, Dr. Howard J.
Federoff, executive vice president of health sciences at Georgetown
University Medical Center.
“The preclinical state of the disease offers a window of opportunity
for timely disease-modifying intervention, and biomarkers defining
this asymptomatic period are critical for successful development and
application of these therapeutics,” says Federoff.
“We consider our results a major step toward the
commercialization of a preclinical disease biomarker test that could
be useful for large-scale screening to identify at-risk
individuals,” Federoff concludes. “We’re intending to design a
clinical trial where we’ll use this panel to identify people at high
risk for Alzheimer’s to test a therapeutic agent that might delay or
prevent the emergence of the disease.”
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