Stem cells differ in ability to differentiate
16 January 2012
Isolated stem cells vary in their characteristics for
regenerative medicine and tissue engineering. In a paper recently
published in the prestigious journal Tissue Engineering the researchers
from the University of Granada and Alcalá de Henares University have
found that only a specific group of cord blood stem cells (CB-SC)
maintained in culture are useful for therapeutic purposes.
At present, CB-SCs are key to regenerative medicine and tissue
engineering. From all types of CB-SC those called "Wharton's jelly
stem cells (HWJSC)" are stirring up the interest of specialists in
regenerative medicine, due to their accessibility and great ability
to develop into several types of tissue and modulate immune
Through a combination of microscopy and microanalysis essays, and
the study of the genes involved in cell viability, the researchers
discovered that only a specific group of cord blood stem cells
(CB-SC) maintained in culture is useful for therapeutic purposes
The most suitable cells
The relevance of this paper, which was the cover article in the
journal Tissue Engineering, lies in the possibility to select the
most suitable HWJSC for tissue engineering and regenerative
medicine. According to these researchers, the different studies with
HWJSC have obtained contradictory results because researchers failed
to previously select the most suitable cell group.
The results of this study also open the possibility to select
stem cell subgroups from different tissues, in order to improve the
therapeutical efficacy of different regenerative medicine protocols.
This research study was conducted by the Tissue Engineering
research group at the University of Granada Histology Department
coordinated by professor Antonio Campos Muñoz, who recently created
artificial skin and a cornea by using stem cells and new
biomaterials developed in Granada.
The research group is also composed of professors Alaminos
Mingorance and Ingrid Garzón. Professor Garzon was awarded a prize
at the World Congress on Tissue Engineering and Regenerative
Medicine held in Seul for a preliminary study on the same issue.
Tissue Eng Part C Methods . 2012 Jun;18(6):408-19.
Evaluation of the Cell Viability of Human Wharton's Jelly Stem Cells
for Use in Cell Therapy.