Sony DADC and Axela to develop smart consumables for
25 January 2012
Salzburg, Austria and Toronto, Canada. Sony DADC and Axela
have entered into a collaboration to develop and manufacture smart
consumables for the dotLab mX detection system.
The dotLab mX System combines automated flow processing with
diffractive optics to enable real-time detection of binding events
and full characterization of biomarkers through sequential probing.
This provides significant analytical advantages for multiplex assay
development and routine analysis in clinical research and
diagnostics. The resultant dynamic range and panel flexibility is
unachievable with any other commercially available product.
Figure 1: The dotLab sensor employs multiple
micropatterned capture areas in a flow channel to create biological
diffraction gratings. When a specific binding event takes place,
the efficiency of the grating improves proportionately. The signal
is monitored in real time and can be used to determine concentration
and avidity of captured analytes. A wide range of materials can
serve as affinity reagents including antibodies, antigens,
carbohydrates, nucleic acids and intact viruses.
Paul Smith, Axela’s COO said: “Axela products can have an
important impact on healthcare by simplifying analysis and
significantly cutting the time from sample acquisition to result.
Uniquely leveraging real time and label free analysis, this assay
platform provides access to new combinations of biomarkers.
Partnering on these advanced consumables will accelerate our
expansion from research markets into applied testing and
“Sony DADC BioSciences is excited to translate its excellence in
manufacturing microstructured polymer devices like optical discs to
the production of the next generation of dotLab® sensors for label
free detection of protein biomarkers, bacteria and viruses.” said
Harald Kraushaar, VP at Sony DADC.
Jessica Melin, Sr. Manager Business Development and Sales North
America commented: “Axela’s demand for high-quality consumables and
our manufacturing capabilities are a perfect match. We provide a
scalable manufacturing solution based on injection molding that
reduces the number of manufacturing steps. Furthermore, our
technology will deliver consumables that are compatible with a
broader range of applications and instrument formats.”
Axela’s VP of Product Development and Manufacturing, Dr. Alex
Izmailov said: “Pairing our innovative platforms with high
performance consumables is the key to success. Sony DADC’s precision
sensors in combination with the inherent self referencing properties
of diffractive optics will make our system highly attractive not
only for biomarker screening and assay development but also as the
method of choice for robust, routine analysis.”
Source: Sony DADC, Axela