Ambry Genetics launches StemArray for high resolution
characterization of human stem cells
11 February 2010
Ambry Genetics has introduced their new StemArray product and
services utilizing aCGH technology to cover the entire genome. The Ambry
StemArray offers a higher resolution approach to standard karyotyping
for stem cells at comparable costs.
The 44K array offers increased coverage in known stem cell and cancer
associated genes to further enhance the resolution in these functionally
"The StemArray is the solution for stem cell scientists that are
working with Human embryonic stem cells and induced pluripotent stem
cells in order to detect genomic abnormalities found in stem cells that
would be missed by low resolution karyotyping," said Ardy Arianpour,
Ambry’s Director of Business Development.
"We are offering the StemArray at a comparable cost to traditional
karyotyping and strongly believe that the product and our service will
help scientists with new discoveries within this market.”
Human embryonic stem (hES) cells and induced pluripotent stem (iPS)
cells that are cultured for an extended period of time are susceptible
to chromosomal instability, which is a big concern for researchers.
Currently, stem cells have been characterized mainly through
traditional low-resolution karyotypic analyses, which can only identify
large scale aneuploidies over 5 MB in size. The Ambry StemArray has an
average resolution of 43KB throughout the genome and 24KB in RefSeq
genes. Resolution is even further enhanced, to the exonic level, in stem
cells and cancer related genes.
“As human stem cells begin to make their way into clinical studies,
it is essential that the cell lines be thoroughly characterized, added
Dr. Aaron Elliott, Ambry’s R&D Scientist, Genomics. Using the StemArray
scientists will not only detect the extremely large copy number changes
that can be found by karyotype, but also identify very small aberrations
that occur during culture that could decrease the reproducibility and
reliability of experimental data.”