Japanese approval for first drug using Elan Drug Technologies' NanoCrystal technology

13 January 2010

Elan Drug Technologies has announced Japanese government approval of the first drug using its NanoCrystal technology.

The drug, Emend (aprepitant), is used for the treatment of cancer chemotherapy-induced nausea and vomiting. It was developed by a subsidiary of Merck & Co Inc., Whitehouse Station, N.J., USA and licensed to Ono Pharmaceuticals Co., Ltd. for the Japanese market.

NanoCrystal technology, enables formulation of poorly water soluble compounds for all routes of administration. For Emend, this technology advance eliminates a food requirement and improves bioavailability by 600%. Emend was confirmed to be effective for both acute and delayed phases of nausea and vomiting in Japanese clinical trials, and becomes the first therapy approved for treatment of delayed phase nausea and vomiting (24 hours or later after start of cancer chemotherapy) in Japan.

“The approval of Emend is a significant achievement for our NanoCrystal technology, as it marks the first Japanese approval of a product incorporating this technology in this very important market,” said Shane Cooke, Executive Vice President and Head of Elan Drug Technologies. “We hope this is the first of many products using our NanoCrystal technology to be launched in Japan.”

NanoCrystal technology is a proprietary technology developed by Elan Drug Technologies through Elan Pharma International Limited and other Elan affiliates. Five licensed products have now been approved using the NanoCrystal technology by various health authorities including the US Food and Drug Administration (FDA). Products incorporating the NanoCrystal technology are sold in markets worldwide.


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