Sigma-Aldrich offers customisable synthetic extracellular matrix for
stem cell research
17 August 2009
Sigma-Aldrich (NASDAQ:SIAL) has announced an agreement with Glycosan
BioSystems for the sale of HyStem, a fully customizable synthetic
extracellular matrix (ECM) for stem cell research.
HyStem offers researchers flexibility to tailor microenvironments for
their cultured cells that mimic natural in vivo conditions, optimizing
stem cell proliferation and differentiation. HyStem was developed by
Glycosan BioSystems and will be sold by Sigma-Aldrich under a
non-exclusive distribution agreement.
The HyStem platform consists of hydrogel cell culture scaffolds that
provide a complex, three-dimensional environment in which cells are able
to proliferate, much as they would in vivo. Composed of hyaluronic acid
and denatured collagen, HyStem’s synthetic matrix offers greater control
of the cellular environment than ambiguous extracted ECM alternatives.
Customizable microenvironments enable researchers to optimize the growth
conditions for each distinct cell type in a multicellular organism.
“Our HyStem ECMs provide a new level of control over the stem cell
growth environment than what was previously available to the research
community. We believe this ECM platform will greatly aid researchers in
advancing global stem cell research,” said Dr. David Smoller, President
of Sigma-Aldrich’s Research Biotech business unit.
“The addition of HyStem products to our portfolio enhances our
position as a leading source of technologies that support the growing
stem cell market.”
The HyStem platform includes three unique options: HyStem, HyStem-C
and HyStem-HP. HyStem is available to researchers who want to customize
their own attachment factors, ECM proteins and peptides, and who require
an animal-component-free system with a minimal number of cell attachment
sites. Researchers requiring a large number of generalized cell
attachment sites for their stem cell cultures will benefit from HyStem-C.
HyStem-HP is available for scientists planning to incorporate and
gradually release growth factors into the stem cell environment. All
options are consistently formulated and well characterized for both in
vivo and in vitro experimentation.
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