Roche completes xCELLigence family of cell analyser products
9 April 2009
Roche Applied Science has now completed its xCELLigence real-time
cell analyzer product line with its newest model, the RTCA DP
Instrument. The xCELLigence system measures impedance-based signals both
in label-free cellular analysis and in cell invasion/migration assays.
The new RTCA DP Instrument (DP is short for dual plate) is applicable
for flexible low-throughput research assays and uses up to three 16-well
plates for simultaneous experiments. In contrast, the RTCA SP and MP
systems cover the demand for medium to high throughput, respectively.
The new RTCA DP Instrument provides real-time cellular analysis with
a high level of flexibility for cell science researchers carrying out
parallel short-term (hours) and long-term (days) assays using
label-free, non-invasive impedance measuring.
The three 16-well plates of the RTCA DP Instrument can be operated
flexibly by three different users; each 16-well E-Plate can be monitored
and analyzed independently. Thanks to its small size, the RTCA DP
Instrument with 16-well E-Plates can be placed in standard CO2
incubators, making it easy to achieve optimum cell culture conditions.
The wide variety of applications include:
- compound-mediated and cell-mediated cytotoxicity;
- cell adhesion and cell spreading;
- cell proliferation and cell differentiation;
- receptor-mediated signaling;
- virus-mediated cytopathogenicity;
- constant quality control of cells;
- cell invasion and migration assays .
xCELLigence RTCA Instruments monitor cellular responses continuously
without exogenous labels by measuring electrical impedance.
Microelectrodes integrated in the bottom of specially engineered tissue
culture E-Plates measure changes and provide precise quantitative
information about the status of cells, including cell number, cell
adhesion, cell viability, and cell morphology.
Continuous impedance monitoring of cell responsivity allows
researchers to pinpoint important experimental time points for more
detailed downstream assays. Impedance measurements represent a
revolution in cellular surveillance compared to single conventional
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