Bruker Daltonics introduces five minute melamine food safety testing
8 January 2009
Bruker Daltonics has released a robust, fast and highly sensitive
high-capacity ion trap HCT solution for the detection and quantification
of melamine and cyanuric acid (CA) by food safety laboratories.
Since September 2008, thousands of infants and young children in
China have been hospitalized to treat the symptoms caused by the
ingestion of melamine and CA contaminated infant formula and related
dairy products. Previously in 2007, pet food, animal feed wheat gluten
and other protein-based foods were found to contain residues of melamine
A five minute, accurate LC-MS/MS analysis method has been developed
by Bruker Daltonics’ food safety development laboratory in Australia.
This robust, easy-to-use and cost-effective method for the extraction,
detection and quantification of melamine and CA uses the speed,
sensitivity and excellent quantitative capabilities of the high-capacity
ion-trap mass spectrometer HCTultraTM, hyphenated with a Dionex
UltiMateTM 3000 LC system and AcclaimTM Mixed-Mode WAX-1 column.
The method is capable of detecting melamine in various matrixes well
below the concentrations required by various food safety and other
regulatory authorities around the world, such as the limits set by the
US Food and Drug Administration (FDA) of 1 ppm for melamine and cyanuric
acid in infant formula, and 2.5 ppm for other foods.
Dr Matthias Pelzing, Asia-Pacific Applications Manager for Bruker
Daltonics, explained: “We recommend LC-MS/MS methods due to their
straight-forward sample preparation, compared to GC-MS methods which
often require sample derivatisation. With our new routine analysis
method we have demonstrated that melamine can be detected down to trace
levels of 0.05 ppb, and that it is possible to quantify melamine at
concentrations relevant to various international food authorities in 5
Mr Clive Seymour, Executive Vice President of Bruker Daltonics,
commented: “Due to its robustness, ease of use, small footprint and
lower cost, our HCT ion trap-based solution offers significant practical
and operational advantages over traditional triple-quad MRM approaches.
In addition, the superior full scan sensitivity of our unique HCT ion
trap technology offers not only outstanding detection limits for
melamine and CA, but also the option of full-scan identification of
other unknown, new or modified food contaminants with superior
The new Bruker Application Note #LCMS-49 on melamine and CA analysis
is available in English, Chinese, Korean, Thai and Japanese, and can be
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