3D MRI imaging highlights brain atrophy in Alzheimer's patients
30 October 2007 Researchers at UCLA have used an advanced 3D mapping
technique to analyse magnetic resonance imaging (MRI) data to highlight the
differences in brain atrophy between mild cognitive impairment and
Alzheimer's disease.

Percent difference in cortical atrophy
between MCI and mild Alzheimer's disease The research team analyzed
magnetic resonance imaging data from 24 patients with amnestic mild
cognitive impairment (MCI) and 25 others with mild Alzheimer’s disease.
Patients in both categories exhibit progressive brain atrophy, with most MCI
patients showing the pathologic changes characteristic of Alzheimer’s. MCI
patients slip into dementia at a rate of 10-15% each year. The research team
found that patients with mild Alzheimer’s had 10-20% more atrophy in most
cortical areas than MCI patients. The research showed the striking
differences in cortical damage between amnestic MCI and mild Alzheimer’s,
and demonstrated that this innovative three-dimensional mapping technique
greatly outperforms other popular 3D imaging techniques such as voxel-based
morphometry
The research was published in the October issue of the Archives of
Neurology.
http://archneur.ama-assn.org/content/vol64/issue10/index.dtl
Reference Liana G Apostolova; Calen A Steiner; Gohar G Akopyan;
Rebecca A Dutton; Kiralee M Hayashi; Arthur W Toga; Jeffrey L Cummings; Paul
M Thompson. Three-Dimensional Gray Matter Atrophy Mapping in Mild Cognitive
Impairment and Mild Alzheimer Disease. Arch Neurol. 2007;64:1489-95.
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