Nanosys and Bruker Daltonics collaborate in technology for fast analysis
of small molecules
21 March 2007
Palo Alto, Calif. & Billerica, Mass., USA. Nanosys, Inc.
and Bruker Daltonics Inc. have entered into a broad R&D collaboration and
distribution agreement. The companies will launch nanotechnology-enabled
small molecule chemical analysis chips for high-throughput laser desorption
ionization mass spectrometry.
Bruker Daltonics will use Nanosys’
matrix-free target plates with its FLEX-series of laser desorption
ionization (LDI) time-of-flight (TOF) mass spectrometers. These Nanosys
plates are known as capture and analyze (CA) NALDI chips.
High-throughput analysis using
NALDI™ chemical analysis chips. The image shows the direct
deposition of samples (with no chemical matrix added) onto the
surface of the Nanosys NALDI chip. (Photo: Business Wire)
NALDI chips enable significant sensitivity, throughput and ease-of-use
benefits for the analysis of small molecules such as drug compounds, small
peptides, natural products, pesticides or many other low mass molecules that
previously were difficult to analyze with the ease and throughput of
MALDI-TOF mass spectrometers. Today, these molecules typically have to be
analyzed with LC-MS (liquid chromatography – mass spectrometry), which is
time-consuming, less robust and requires more operator training.
chips combined with the fast and easy-to use TOF or TOF/TOF mass
spectrometers have the potential to revolutionize small-molecule mass
spectrometry in many important areas of life science or chemical research
and analysis. Potential applications include chemistry and molecular biology
research, molecular diagnostics and molecular imaging research,
pharma/biotech and other industrial research and analysis, as well as many
applied fields, such as food analysis, environmental analysis, toxicology,
Under the terms of the collaboration agreement, the companies will
collaborate closely on R&D related to the NALDI chips, as well as on
applications and assay development. Nanosys will manufacture and exclusively
supply NALDI chips for Bruker LDI-TOF mass spectrometers, while Bruker
Daltonics will market and distribute the innovative NALDI chips worldwide.
Financial details of the agreement were not disclosed.
“We are excited to
be partnering with Bruker Daltonics to bring our NALDI chip products to
market,” said Calvin Chow, Nanosys' Chief Executive Officer. “Bruker is a
clear leader in the area of chemical analysis and life sciences research.
They understand how to take breakthrough technology products successfully
into high value markets.”
Frank Laukien, Ph.D., President and CEO of Bruker Daltonics, commented: "The
unique capabilities offered by the Nanosys NALDI chips in combination with
our industry-leading TOF and TOF/TOF mass spectrometers open up a breadth of
new research and applied market opportunities for the easy, fast and robust
analysis of small molecules.”