Chip-based cell monitoring system for preclinical pharmacological
28 August 2006
Bionas GmbH has launched a device for in vitro profiling of the
metabolic activity of cells to understand cellular function. The Bionas 2500
is a bench-top instrument that measures multiple metabolic parameters
simultaneously, such as acidification, oxygen consumption and adhesion of
living cells for high quality and predictive safety pharmacological studies
during preclinical phases of drug discovery.
label-free and non-invasive live cell-based assay employs sensor chips that
replace the conventional bottom of culture wells. Various cell types
including primary cells have been successfully tested. The readout is
carried out continuously over long periods of time and can be viewed online,
revealing a deeper insight in cellular function than possible with
endpoint-based assays. Regeneration effects can also be monitored.
Bionas 2500 analyzer closely mimics the in vivo situation and also:
- aids compound selection during preclinical phases of drug discovery;
- reduces needless animal studies; and
- saves money due to reduction of development time.
he main applications include drug profiling, lead optimization, early
toxicology programs, ADME/Tox, chemosensitivity testing, toxicological
testing of chemical substances (REACH) and cell culture